I have pain at night in my left knee from IT band friction syndrome. Is there anything that could help ease this?

Rest, ice and anti-inflammatory remedies are the first step, alongside resting from the activity that initially caused the problem (often running or cycling). 

Devil's Claw is a useful natural anti-inflammatory, which can be taken alongside pain medication. 

Gentle stretching and strengthening exercises come next, and it's best to do these under the supervision of a physiotherapist or other sport-orientated practitioner, who can assess your case, personalise the exercises, and monitor your progress back to full activity.